[ensembl-dev] VEP server blocks https requests

[Mark McDowall]

Hi Rokhaya,

A 429 error highlights that you are hitting the rate limit for a client to the service:

https://github.com/Ensembl/ensembl-rest/wiki/HTTP-Response-Codes

Have a look at the following documentation for the defined rate limits for the service:

https://github.com/Ensembl/ensembl-rest/wiki/Rate-Limits

You'll need to throttle your code by monitoring the headers to avoid getting the 503 errors

Hope this helps,

Mark

On 21/03/2019 11:02, Rokhaya BA wrote:
> Hello,
> 
> I am a PhD student in bioinformatics within the CRTI in Nantes, France.
> 
> I am developing Ferret (http://limousophie35.github.io/Ferret/), a Java application designed to retrieve annotations  from the 
> VEP REST API using variants id (rsid). This application submits a https request and extract the sift/polyphen scores and 
> predictions from the JSON output.
> 
> However, VEP server usually shut down my requests after some iterations. Please see below some examples of errors returned by 
> the app:
> 
> /Server returned HTTP response code: 429 for URL: https://rest.ensembl.org/vep/human/id/rs41282276?content-type=application/json/
> 
> /Server returned HTTP response code: 503 for URL: https://rest.ensembl.org/vep/human/id/rs543148494?content-type=application/json/
> 
> In practice, I use threads to speed up my runtime. Then, the application submits many requests in a short amount of time.
> 
> I wanted to know if there is any way to solve this issue?
> 
> Thank you very much for your help.
> 
> Best regards,
> 
> Rokhaya BA
> 
> PhD Student in Bioinformatics
> 
> 
> 
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-- 
Mark McDowall, PhD | Bioinformatician, Ensembl
European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
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WWW: http://www.ensembl.org
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