[ensembl-dev] Using current VEP versions with old caches

[Will McLaren]

Hi John,

I've just run a basic test and it seems to work fine for basic consequence
calling.

We don't make any guarantees on backwards compatibility of software/cache
combinations. You may run into issues using, for example, --check_existing
or --sift.

Regards

Will McLaren
Ensembl Variation

On 2 March 2017 at 20:58, John M.C. Ma <manchunjohn-ma at uiowa.edu> wrote:

> Hi all,
>
> To put it simply, does modern versions of VEP (85, 86 or 87 are fine)
> work with the old VEP cache archives from the Ensembl FTP site?
>
> Specifically, my collaborator have some data that would preferably be
> analyzed with mm9, and the last Ensembl release with this assembly is
> e67. While I haven't attempted to run VEP with this cache, my attempt
> in using convert_cache.pl in VEP85 or 86 failed.
>
> So, can anyone confirm whether I can use an old VEP cache with a newer
> VEP or not? Thanks!
>
> Cheers,
>
> John MC Ma
> Postdoctoral Fellow
> Department of Lymphoma/Myeloma
> University of Texas MD Anderson Cancer Center
> Houston, Texas, USA
>
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