[ensembl-dev] Genome build and annotator for new large scale WGS project

[Thibaut Hourlier]

Hi Genomeo,
You should use GRCh38 as it is an improved version of GRCh37

What exactly do you want to annotate?

Thanks
Thibaut

> On 19 Apr 2016, at 10:30, Genomeo Dev <genomeodev at gmail.com> wrote:
> 
> Dear all,
> 
> We are trying to generate whole genome sequences for 25,000 samples using short read data form Illumina. This will be used in many downstream analyses and other related projects.
> 
> 1) Would you recommend to go for GRCH37 or GRCH38?
> 
> 2) For the annotation, what are the main advantages to adopting VEP as the annotator tool? especially in linking with public databases and comparing to other genomics studies.
> 
> Thank you,
> 
> -- 
> G.
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