[ensembl-dev] Genome build and annotator for new large scale WGS project

Genomeo Dev genomeodev at gmail.com
Tue Apr 19 10:30:55 BST 2016


Dear all,

We are trying to generate whole genome sequences for 25,000 samples using
short read data form Illumina. This will be used in many downstream
analyses and other related projects.

1) Would you recommend to go for GRCH37 or GRCH38?

2) For the annotation, what are the main advantages to adopting VEP as the
annotator tool? especially in linking with public databases and comparing
to other genomics studies.

Thank you,

-- 
G.
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