[ensembl-dev] Genome build and annotator for new large scale WGS project

Genomeo Dev genomeodev at gmail.com
Tue Apr 19 11:14:03 BST 2016


Thanks. Aim is to annotate with the predicted functional consequences based
on what is publicly known about the genome annotation. Sort of what you get
from VEP.

G.

On 19 April 2016 at 12:51, Thibaut Hourlier <thibaut at ebi.ac.uk> wrote:

> Hi Genomeo,
> You should use GRCh38 as it is an improved version of GRCh37
>
> What exactly do you want to annotate?
>
> Thanks
> Thibaut
>
> > On 19 Apr 2016, at 10:30, Genomeo Dev <genomeodev at gmail.com> wrote:
> >
> > Dear all,
> >
> > We are trying to generate whole genome sequences for 25,000 samples
> using short read data form Illumina. This will be used in many downstream
> analyses and other related projects.
> >
> > 1) Would you recommend to go for GRCH37 or GRCH38?
> >
> > 2) For the annotation, what are the main advantages to adopting VEP as
> the annotator tool? especially in linking with public databases and
> comparing to other genomics studies.
> >
> > Thank you,
> >
> > --
> > G.
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-- 
G.
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