[ensembl-dev] VEP Rest API very slow

Sarah Hunt seh at ebi.ac.uk
Thu Jul 19 16:41:13 BST 2018


Hi Beat,

We are looking into this, but in the meantime, the archive of our e!92 
release is available here:  http://wp-p1m-6e.ebi.ac.uk:5000

It should be available as: http://e92.rest.ensembl.org/ shortly.

Sarah

On 19/07/2018 16:08, Wolf Beat wrote:
> Hello,
>
>
> i was wondering why the ensembl VEP rest API is very slow.
>
> When i try for example this query:
>
> http://rest.ensembl.org/vep/hsapiens/id/rs539044217?content-type=application/json<http://rest.ensembl.org/vep/hsapiens/id/rs539044217?distance=-100000&content-type=application/json>
>
>
> It takes up to 10 seconds.
>
> It seems like the issue is not related to the actual VEP work (effect prediction), because if i add the following parameter:
>
> http://rest.ensembl.org/vep/hsapiens/id/rs539044217?distance=-100000&content-type=application/json
>
>
> thus removing basically all genes from the prediction, it takes an equal amount of time.
>
>
> This is quite an urgent issue for me. Is there a faster way to retrieve frequences (ok that one i know) AND polyphen/sift predictions in the same query, that is faster?
>
>
> Kind regards
>
>
> Beat Wolf
>
>
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