[ensembl-dev] VEP Rest API very slow

[Wolf Beat]

Hello,


i was wondering why the ensembl VEP rest API is very slow.

When i try for example this query:

http://rest.ensembl.org/vep/hsapiens/id/rs539044217?content-type=application/json<http://rest.ensembl.org/vep/hsapiens/id/rs539044217?distance=-100000&content-type=application/json>


It takes up to 10 seconds.

It seems like the issue is not related to the actual VEP work (effect prediction), because if i add the following parameter:

http://rest.ensembl.org/vep/hsapiens/id/rs539044217?distance=-100000&content-type=application/json


thus removing basically all genes from the prediction, it takes an equal amount of time.


This is quite an urgent issue for me. Is there a faster way to retrieve frequences (ok that one i know) AND polyphen/sift predictions in the same query, that is faster?


Kind regards


Beat Wolf