[ensembl-dev] Question about "X"

[Sarah Hunt]

Dear Ken,

Yes - "X".  does signify a stop in this context, the same as "*" or 
"Ter". Thanks for bringing this to our attention - the "X" is the old 
style of notation so we will update it for our next release.

Best wishes,

Sarah


On 02/09/2014 20:16, Chen,Ken wrote:
> Dear group, we are users of VEP,
>
> We've seen a few examples in our data where the p.HGVS gives an "X".  
> Is this the same as a*, meaning truncation?
> Examples:
> ·H64IfsX35: My interpretation being an insertion or deletion of 
> nucleotides caused a substitution at codon 64 (H to I) that also 
> resulted in a premature stop codon 35 amino acids from codon 64.
> ·T319X: My interpretation being that an insertion or deletion of 
> nucleotides caused a mutation from T to a stop codon.
>
> You answer will be greatly appreciated.
>
>
> -Ken
>
>
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