[ensembl-dev] Genes with identical symbols but different ENSG

[Duarte Molha]

Hi

Still would like an answer to this if possible

Thanks

Duarte


On Fri, 22 Mar 2019 at 08:59, Mark McDowall <mcdowall at ebi.ac.uk> wrote:

> Hi Duarte,
>
> We are looking into this at the moment.
>
> Cheers,
>
> Mark
>
> On 19/03/2019 14:13, Duarte Molha wrote:
> > Dear Devs
> >
> > Could you help me understand why the gene
> >
> > ATXN7
> >
> > Has 2 ENSG ids. but they both map to the same external Reference:
> > ATAXIN 7; ATXN7 [*607640] (MIM gene record; description: ATAXIN 7;
> ATXN7,)
> >
> > The Gene with the most transcripts associated with it is:
> > ATXN7 (Human Gene)
> > ENSG00000163635 3:63898399-64003453:1
> >
> > But Overlapping with it you have
> > ATXN7 (Human Gene)
> > ENSG00000285258 3:63864557-64003462:1
> >
> > Would it not make sense to add all transcript to the 1st ID and drop the
> second?
> > This unfortunately is not the only gene where this occurs
> >
> > For example the HGNC symbol DIABLO is associated with 2 ENSG IDs (also
> overlaping
> > The same with CCDC39, IGF2, MATR3, PDE11A, RMRP, SCO2, SPATA13 and TBCE
> >
> > I am sure this is not the only ones where this is true and it creates a
> bit of a problem because now I need to be merging
> > distinct entities or choose between one of the 2 entries as the main
> entry for that gene symbol.
> >
> > Your help on why this occurs and any possible solutions as to how to
> only select the main one would me much appreciated
> >
> > Best regards
> >
> > Duarte Molha
> >
> > _______________________________________________
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>
> --
> Mark McDowall, PhD | Bioinformatician, Ensembl - Multiscale Genomics
> European Bioinformatics Institute (EMBL-EBI)
> European Molecular Biology Laboratory
> Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
> Tel: +44-(0)1223-494589
> WWW: http://www.ensembl.org
> WWW: http://www.multiscalegenomics.eu
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