[ensembl-dev] VEP differences in REST interface (grch37 vs grch38)

Ben Moore bmoore at ebi.ac.uk
Tue Jun 4 15:54:26 BST 2019


Hi Harshit,

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Best wishes

Ben

> On 4 Jun 2019, at 15:48, Harshit <harshitag785 at gmail.com> wrote:
> 
> Please someone unsubscribe me from this list. I do not want to receive these mails at all.
>  
> Sent from Mail <https://go.microsoft.com/fwlink/?LinkId=550986> for Windows 10
>  
> From: Wolf Beat <mailto:Beat.Wolf at hefr.ch>
> Sent: 04 June 2019 20:17
> To: dev at ensembl.org <mailto:dev at ensembl.org>
> Subject: [ensembl-dev] VEP differences in REST interface (grch37 vs grch38)
>  
> Hi,
>  
>  
> i'm having an issue where several variants are missing MAF information in the grch37 rest api since the last release (they had the information previously).
>  
>  
> One example would be:
>  
>  
> http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=2:179616271-179617271;v=rs58651353;vdb=variation;vf=75079740 <http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=2:179616271-179617271;v=rs58651353;vdb=variation;vf=75079740>
>  
>  
> This variants shows a MAF in multiple databases on the website, yet, in the REST API it does not:
>  
> http://grch37.rest.ensembl.org/vep/hsapiens/id/rs58651353?distance=0&content-type=application/json <http://grch37.rest.ensembl.org/vep/hsapiens/id/rs58651353?distance=0&content-type=application/json>
>  
>  
> Yet, when accessing the latest rest backend, the information is present:
>  
>  
> http://rest.ensembl.org/vep/hsapiens/id/rs58651353?distance=0&content-type=application/json <http://rest.ensembl.org/vep/hsapiens/id/rs58651353?distance=0&content-type=application/json>
>  
>  
> Are there additional parameters i have to set for the grch37 backend or is this a bug? I can give examples of more variants with that issue (eg. rs659243)
>  
>  
> Kind regards
>  
>  
> Beat Wolf
>  
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Ben Moore
Ensembl Outreach Officer

European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
Wellcome Trust Genome Campus
Hinxton
Cambridge
CB10 1SD
UK

bmoore at ebi.ac.uk
+44 (0)1223 494265

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