[ensembl-dev] Are the IP address(es) for useastdb.ensembl.org fixed/static?

[Sarah Hunt]

Hi Kevin,

Using VEP via remote databases can be slow, so we would recommend 
downloading cache files of annotation and fasta files of genomic 
sequence for more efficient local use. There is information on how to do 
this here:

http://www.ensembl.org/info/docs/tools/vep/script/vep_cache.html

Best wishes,

Sarah


On 08/02/2018 19:48, Steve Trevanion wrote:
>
> Hi Kevin,
>
> ensembldb.ensembl.org is hosted at EMBL-EBI and the IP is stable.
>
> So you need to use port 5306 for all applications.  I guess you could 
> set it as an environment variable and then use that in your scripts 
> (http://www.ensembl.org/info/docs/api/registry.html) but that's not 
> very elegant. Can anyone from Ensembl @core or @variation comment ?
>
> Cheers,
>
> Steve
>
>
>
> On 08/02/2018 03:48, Ernst, Kevin wrote:
>> Hi Steve, thanks for your reply. I'll share that information with our 
>> research IT people and see what they say.
>>
>> What about ensembldb.ensembl.org (ensembldb.ebi.ac.uk)? That does not 
>> appear to be hosted with AWS. Is that IP (or that of the load 
>> balancer, if there is one) likely to change on a whim, or have they 
>> been fairly stable? Perhaps that's our only option.
>>
>> I have an additional question about the MySQL port number as well. I 
>> was unable to convince our organizational network security team to 
>> make exceptions for the "standard" port 3306 (which is, sadly, 
>> opposite the motivation described in this Ensembl blog post 
>> <http://www.ensembl.info/2013/05/02/database-port-changes/>).
>>
>> So... will Ensembl tools like VEP generally try one port and then the 
>> other, or is there a way we could globally configure anything using 
>> the Perl API to prefer the non-standard port number—for all users of 
>> our cluster? Perhaps with a Makefile.PL flag, or an environment variable?
>>
>> (I see that creating an /etc/skel/.vep/vep.ini for new users is one 
>> potential option for VEP, for example, but there are hundreds of 
>> existing users, so setting an environment variable in our Environment 
>> Modules modulefile for VEP would work much better.)
>>
>> Thanks very much.
>>
>> Cheers,
>> Kevin Ernst
>>
>>
>> On 07.02.18 19:07, Steve Trevanion wrote:
>>> Can you speak again with your IT colleagues ? I am not a specialist 
>>> in this area so I will talk next week with members of the EMBL-EBI 
>>> network team to see if they can suggest any ways around this.
>>
>
>
>
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