[ensembl-dev] Lock on index file

Will McLaren wm2 at ebi.ac.uk
Tue Dec 9 18:50:17 GMT 2014

Hi Konrad,

Sounds like an issue with Bio::DB::Fasta, which is part of the BioPerl
module set that we don't maintain.

A quick Google brought up this:


which might be of some help; perhaps it depends on the index type that it
chooses to create (http://search.cpan.org/~cjfields/BioPerl/Bio/DB/Fasta.pm

It may also be a filesystem thing - I know NFS can have issues with
multiple processes accessing the same file.



On 9 December 2014 at 18:40, Konrad Karczewski <konradk at broadinstitute.org>

>   Hi dev team,
> I'm confused by an error I've been occasionally getting recently. I've
> created a sequence index using a test VEP run (and verified it's written
> and gets read by a test run without a problem), and then submit ~a few
> hundred VEP jobs to a cluster. A small subset of them come up with this
> error:
> Can't open sequence index file
> /humgen/atgu1/fs03/konradk/vep/gold//homo_sapiens/77_GRCh37/Homo_sapiens.GRCh37.75.dna.primary_assembly.fa.index:
> No locks available at
> /humgen/atgu1/fs03/konradk/ensembl-tools-release-77/scripts/variant_effect_predictor/Bio/DB/Fasta.pm
> line 527.
> I would have thought if the index existed and was readable, it wouldn't
> try to write it, but asking for a lock seems to suggest it is: any ideas
> what may be causing this? This happens on at least on VEP versions 77 and
> 78.
> Thanks!
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