[ensembl-dev] Possibly incorrect entrezgene ids for CCL3L1, CCL3L1, HLA-DQA2
Gerhard Burger
g.a.burger at lacdr.leidenuniv.nl
Tue Nov 3 14:07:41 GMT 2020
Hi ensemble-dev,
I'm trying to get entrizid for hgnc gene symbols, but I got some confusing
results for CCL3L1, CCL3L1, HLA-DQA1, HLA-DQA2. I am using the following R
code:
library(biomaRt)
ensembl <- useEnsembl(biomart = "genes", dataset =
"hsapiens_gene_ensembl")
getBM(values = c("CCL3L1", "CCL3L3", "HLA-DQA1", "HLA-DQA2"),
attributes = c("entrezgene_id", "hgnc_symbol"),
filters = "hgnc_symbol", mart = ensembl)
which gives:
entrezgene_id hgnc_symbol
1 6349 CCL3L1
2 414062 CCL3L1
3 6349 CCL3L3
4 414062 CCL3L3
5 3117 HLA-DQA1
6 3117 HLA-DQA2
7 3118 HLA-DQA2
However, when I look up these hgnc symbols online I believe the result
should be:
entrezgene_id hgnc_symbol
1 6349 CCL3L1
2 414062 CCL3L3
3 3117 HLA-DQA1
4 3118 HLA-DQA2
The online sources:
CCL3L1:
https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10628
CCL3L3:
https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30554
HLA-DQA1:
https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4942
HLA-DQA2:
https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4943
Also AnnotationDbi does give me the expected results:
require(AnnotationDbi)
require(org.Hs.eg.db)
AnnotationDbi::mapIds(org.Hs.eg.db,
keys=c("CCL3L1", "CCL3L3", "HLA-DQA1", "HLA- DQA2"),
column = "ENTREZID", keytype = "SYMBOL")
Am I doing something wrong or is this is bug?
(biomaRt version 2.44.4, ensemble version 101)
Kind regards,
Gerhard
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