[ensembl-dev] Transmembrane feature in Ensembl protein summary

[Genomeo Dev]

Hi,

While transmembrane regions in Ensembl protein summary are based on TMHMM:

http://www.ensembl.org/Help/View?id=177

It is interesting to find that for some proteins with established number of
transmemrbane helices such as GPCRs e.g. , Ensembl shows 6 predicted TMs
for the merged ensembl-havana transcript protein ENSP00000355316. The
corresponding Uniprot ID (Q14832) shows the correct number of 7 TM helices:

TMH1
Uniprot Transmembrane 577 – 599 23 Helical; Name=1; Potential
Ensembl Transmembrane 577 599
TMH2
Uniprot Transmembrane 614 – 634 21 Helical; Name=2; Potential
Ensembl Transmembrane 612 634
TMH3
Uniprot Transmembrane 646 – 664 19 Helical; Name=3; Potential
TMH4
Uniprot Transmembrane 689 – 709 21 Helical; Name=4; Potential
Ensembl Transmembrane 687 709
TMH5
Uniprot Transmembrane 735 – 756 22 Helical; Name=5; Potential
Ensembl Transmembrane 737 756
TMH6
Uniprot Transmembrane 770 – 792 23 Helical; Name=6; Potential
Ensembl Transmembrane 771 793
TMH7
Uniprot Transmembrane 803 – 828 26 Helical; Name=7; Potential
Ensembl Transmembrane 806 828

http://www.uniprot.org/uniprot/Q14832

Would be useful if protein features from sources such as uniprot can be
checked against/incorporated into Ensembl.

Best regards

-- 
G.
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