[ensembl-dev] determining non-synonymous variants

[Ryan Giuliany]

Hi,

I need to be able to determine, for a list of chromosomal positions, if each will result in amino acid substitution or not.

I've searched around online and gone through the perl API's but I'm not seeing an overly straightforward way of achieving this.  For example, I could possibly do it by retrieving the overlapping transcript, copying it, modifying the base in question, translating both the original and the copy and comparing the peptides, but this seems…unnecessarily complex.

Is there an easy way that I've missed?

Thanks!!
Ryan