[ensembl-dev] Genebuild question - The transcript consensus module

[Simon White]

Hi,
BestTargetd is used for filtering overlapping sets of targeted  
(species specific) models to select the ones that most closely  
resemble the  original protein sequence,
TranscriptConsensus is generally used for comparing models built from  
non-species specific evidence with ESTs to select the best supported  
models.
  If you are annotating a human genome using human protein / cDNA  
then TranscriptConsensus is probably not necessary, just BestTargeted.


Hope that helps,

Simon White

On 20 Jun 2011, at 13:42, wenkai jiang wrote:

> Hi,
>
> currently, we have sequence a genome very close to a known genome.  
> ie. annoate an asian human genome  based on known human genes.
>
> I have finished running  Pmatch, Blastminiwise, Bestargetted.
>
> but i have no idea about further analyses.
>
> could i run genebuilder based on the result of 'besttargetted'?
> or i must run 'transcipt consensus' after besttargetted, then run  
> the genebuild process?
>
> the doc said that both besttargeed and transcript consensus are  
> methods for filtering the geneset.
>
> what is the relationship between these two methods?
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