[ensembl-dev] GRCh37 Fix Patches - Is Base Numbering Affected?

Bio X2Y bio.x2y at gmail.com
Tue Oct 26 14:43:48 BST 2010


Hi,

I was wondering how Ensembl implements the GRCh37 'fix' patches - in
particular how the numbering of the fixed chromosome is affected.

e59 uses GRCh37.p1, which has only one fix patch (HG79_PATCH on chr9). Since
the new region is larger than the chr9 region it replaces, does this mean
that the numbering system for the remaining part of chr9 has been
incremented and  the gene annotations updated accordingly?

If not, how are the bases in the new region numbered for the purposes of
annotation?

Thanks
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